Daniel A. Grande is full Professor and Director of Orthopedic Research at the Feinstein Institute for Medical Research, part of the Northwell Health System, NY, USA. He is also Professor at the Hofstra School of Medicine, NY, USA. Dr Grande graduated from New York University with a degree in anatomy and cell biology. He did a postdoctoral fellowship at the Hospital for Special Surgery in New York, NY, USA, focusing on biomechanics of cartilage. He has contributed more than 125 peer reviewed papers and seven book chapters to the literature with many involving cartilage repair strategies. His early work developed the first use of cell-based therapy for cartilage repair, currently known as autologous chondrocyte transplantation. His current work focuses on regenerative medicine of the musculoskeletal system using combinations of stem cells, growth factors and scaffolds. Recent work has focused on OA using exosomes as a therapeutic agent.